As electrohydrodynamic atomisation (EHDA) continues to revolutionise pharmaceutical and drug delivery research in recent decades, the focus is beginning to shift towards the safety of the process for obvious reasons, a key component of the process is the use of a high-voltage power supply. This provides researchers and industries with an efficient way to fabricate nanofibres for applications in drug design, biomedicine, filtration, energy storage, and textiles in a process known as ‘electrospinning’. Typically, the range of high-voltage power supplied during an EHDA procedure is usually from 1 kV to 100 kV. This can pose safety hazards if not handled properly.
To ensure a safe and efficient electrospinning setup, it is crucial to understand best practices for using high-voltage power supplies. This guide will cover the key safety measures, precautions, and best practices to protect users and equipment in EHDA applications such as electrospinning.
Understanding High-Voltage Power Supplies in Electrospinning
It is crucial to obtain the relevant training adequate for operating a power supply before doing so. Electrospinning relies on high-voltage electric fields to draw polymer solutions into ultra-thin fibres. The main components of an electrospinning system include:
- High-voltage power supply – Generates the electrical forces required for fibre formation.
- Syringe pump – Controls the flow rate of the polymer solution.
- Spinneret (needle/nozzle) – Dispenses the polymer solution.
- Collector – Captures the electrospun fibres.
A typical electrospinning setup requires voltages between 10 kV and 30 kV, though specialised upscaled applications may require higher voltages. Ensuring proper grounding, insulation, and protective measures is essential to prevent accidents during the procedure.
Key Safety Measures for High-Voltage Electrospinning
1. Use Proper Insulation and Grounding
Why it matters: High-voltage systems can create dangerous electrical discharges if not properly insulated or grounded.
Best Practices:
- Always use a dedicated and approved ground connection for your power supply.
- Ensure all cables and exposed conductive components are properly insulated.
- Keep all metal surfaces properly grounded to prevent accidental shocks or arcing.
2. Maintain a Safe Distance from High-Voltage Components
Why it matters: High voltage can ionise air and cause arc discharge, leading to potential electric shocks. It is essential to work in a clean and spacious environment when operating a power supply.
Best Practices:
- Maintain at least 30 cm (12 inches) distance from the high-voltage components.
- Use non-conductive barriers or acrylic shields around the electrospinning area.
- Don’t handle live components during operation.
3. Wear Personal Protective Equipment (PPE)
Why it matters: Direct contact with high-voltage sources can cause serious injury or hazards.
Best Practices:
- Wear insulated gloves and a lab coat to reduce the risk of exposure.
- Use plastic protective eyewear to guard against accidental arcing.
- Avoid wearing conductive jewellery or accessories while operating the system.
4. Control Environmental Conditions
Why it matters: Humidity, temperature, and airflow can affect both the electrospinning process and air conductivity.
Best Practices:
- Operate in a controlled low-humidity environment to prevent electrical discharge variations.
- Ensure proper ventilation to avoid the build-up of solvent vapours.
- Keep the work area dry and free from flammable materials.
5. Ensure Safe Power Supply Handling
Why it matters: Improper handling of high-voltage power supplies can result in severe electric shocks.
Best Practices:
- Always turn off the power supply before making any adjustments.
- Use interlock switches to automatically cut power when the system is accessed.
- Regularly inspect cables and connections for wear and damage.
6. Use Proper Emergency Procedures
Why it matters: Accidents can happen, and knowing the right steps can prevent injury.
Best Practices:
- Clearly mark emergency shut-off switches.
- Keep a first-aid kit and fire extinguisher nearby.
- Train all personnel on electrical safety protocols and emergency response actions.
Common Hazards in Electrospinning & How to Mitigate Them
|
Hazard |
Potential Risk |
Preventive Measures |
|
Electrical Shock |
Contact with high-voltage sources |
Proper insulation, PPE, grounding |
|
Arc Discharge |
Ionisation of air causing sparks |
Maintain safe distance, control humidity |
|
Solvent Vapours |
Inhalation of toxic fumes |
Ensure adequate ventilation, use fume hoods |
|
Fire Hazards |
Flammable solvents near high voltage |
Keep workspace free from ignition sources |
Final Thoughts
High-voltage power supplies are essential for electrospinning, but safety should always be a top priority. By implementing these best practices—proper grounding, insulation, PPE, environmental controls, and emergency procedures—you can ensure a safe and efficient electrospinning operation.
At Genvolt, safety is our topmost priority, hence, we provide high-quality, safe, and reliable high-voltage power supplies tailored for EHDA applications. We also specialise in syringe pumps and accessories designed for EHDA applications. Whether you’re developing next-generation drug delivery systems or high-performance nanofibre materials, our advanced technology ensures reliability and precision in your research.
Contact Genvolt today by sending us your enquiries to explore our cutting-edge solutions!
Explore our range of high-voltage power supplies and other accessories for electrospinning applications Here.